28-11-12 Pluripotent Stem Cell Landscapes

Home Programme 2013-2014 Previous programmes Contact us Committee Directions History

The Sir Martin Evans Lecture

Sponsored by Cardiff University

Pluripotent Stem Cell Landscapes

Professor Austin Smith BA PhD FRSE FRS

Wellcome Trust and Medical Research Council

Stem Cell Research Institute

Abstract

Pluripotency, the capacity to generate all cell types of the body, lies at the foundation of development in mammals. A small group of pluripotent cells emerge before implantation in the blastocyst. They remain in a naive state only transiently before beginning specification towards different lineages. In 1981, however, scientists discovered that pluripotency could be maintained in cell culture. The resulting embryonic stem (ES) cells can self-renew indefinitely while retaining full differentiation potential and embryonic identity. Study of ES cells over the intervening 30 years has revealed unique molecular features that underlie

pluripotency. These studies have also highlighted profound differences between ES cells from mice and human cell lines. Deeper understanding of ground state pluripotency is therefore needed.

28th November 2012

Large Chemistry Lecture Theatre
Cardiff University

A drinks reception will be available from 6.45pm

in the Viriamu Jones gallery

2-10-13 Challenge Chemistry 16-10-13 The Sir Martin Evans Lecture 30-10-13 The Commercialization and Exploitation of Knowledge 13-11-13 Sir Humphry Davy 27-11-13 Strategies for Brain Repair 11-12-13 Breathing is bad for your Health 9-01-14 Ecological Consequences of Climate Change 22-01-14 On the Geological Disposal of Nuclear Waste 5-02-14 The Lord Phillips Memorial Lecture 19-02-14 Malaise associated with Upper Respiritary Tract 5-03-14 Designing for the Flintstones: How the products of the 12-03-14 Europe’s Cosmic Explorers

Programme 2012-2013 Programme 2011-2012 Programme 2010-2011 Programme 2009-10 Programme 2008-9 Programme 2007-8 Programme 2006-7 Programme 2005-6

3-10-12 Some queues I've enjoyed 17-10-12 The Perfect Football Pitch 31-10-12 Engineered Surfaces 14-11-12 Understanding Abrupt Climate 28-11-12 Pluripotent Stem Cell Landscapes 12-12-12 Ecological Consequences of Climate Change 9-1-13 What is it like to be a Bat 23-1-13 Drug Discovery 6-2-13 Wizards and Luddites 20-2-13 Nuclear Spectroscopy 6-3-13 Volcanoes and Society 13-3-13 AGM 20-3-13 Solar Max

Ignite lecture

18-5-12 5-10-11 Small Changes: Major Differences 19-10-11 People, Plants and Genes The Story of Crops and Humanity 2-11-11 Nuclear Reprogramming by Eggs and Oocytes 16-11-11 Cassini-Huygens mission at Saturn and Titan 30-11-11 Numbers, Numbers Everywhere 14-12-11 The Art and Science of Endocrine Surgery 11-01-12 Modelling Chemistry 25-01-12 The Psychology of Climate Change 08-02-12 The Newport Medieval Ship 22-02-12 Alcohol and Violence 7-03-12 Good Vibrations 21-03-12 Phoenix from the Ashes

6-10-10 Catalysis by Gold 20-10-10 The Science of Common Things 3-11-10 Mice, Men and Medicine 17-11-10 The 300 Million Years War 1-12-10 Rock Climbers 12-01-11 Drug Discovery 26-01-11 The Consequences of Chernobyl 9-02-11 Below the Salt 16-02-11 Jet Streams in Weather and Climate 23-02-11 Smoking Supernovae 9-03-11 With Scott in the Antarctic 23-03-11 The Colour of Fossil Birds and Dinosaurs from China

7-10-09 Controlling emissions from passenger cars 21-10-09 Creative Value Engineering of Bridges and Buildings 4-11-09 Smoking Supernovae 18-11-09 Lasers: Principles, Progress and People 2-12-09 Two Darwins for the price of one 16-12-09 Hypoxic Homer 6-1-10 Supporting Olympic Athletes 20-1-10 Towards a Sustainable Future 3-02-10 The Genetics underlying late-onset Alzheimer’s Disease 17-02-10 A New View of Seafloor Spreading at the Mid-Atlantic Ridge 3-3-10 Recent Advances in Mapping the Human Brain 17-3-10 Txt Crimes, Sex Crimes and Murder – the Emerging Science of Forensic Linguistics

1-10-08 Endangered Species Research 15-10-08 The Herschel & Planck satellites 29-09-08 The Infinite 12-11-08 Rescuing the Leaning Tower 26-11-08 Asprin 10-12-08 Towards health care for Africa 07-01-09 Nanotechnology 21-01-09 Antimatter in the Universe 4-2-09 The Severn Barrage 18-2-09 Nuclear Energy: a Risk worth taking? 4-3-09 William Smith 18-3-09 Why can't a man be like a woman

History 2 History 3