Drug discovery is a very long and tortuous process. This process will be described
with reference to the speaker's direct experience in the development of new experimental
treatments for viral infections, cancer, and arthritis. At the time of writing the
McGuigan lab have a new agent for shingles and a promising new drug for hepatitis
C virus, both in phase 2 human trials, and a new agent for pancreatic cancer about
to enter human trials. All 3 were discovered in our labs in Cardiff. One of these
agents was recently bought out by Bristol Myers Squibb for a record breaking $2.5
bn; the science behind this deal will be described. Studies further back in the pipeline,
such as the lab's work on arthritis, will be described, with an overview of the challenges
and opportunities for future work in drug discovery within academia and beyond.
23rd January 2013
Large Chemistry Lecture Theatre Cardiff University
A new molecule, code-named Cf1743:
the most powerful agent ever against the VZV virus, which causes chickenpox and shingles.